Compounded Semaglutide

What semaglutide is used for

Semaglutide is a GLP-1 receptor agonist prescribed, where appropriate, for chronic weight management alongside changes to diet and activity. On Conduit, a licensed physician reviews your health history, decides whether semaglutide is appropriate for you, sets your individual dose, and re-evaluates it at every monthly check-in.

Who should not use semaglutide

• Anyone with a personal or family history of medullary thyroid carcinoma (MTC).
• Anyone with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
• Anyone with a prior serious hypersensitivity reaction to semaglutide or its components.
• Anyone who is pregnant, planning to become pregnant, or breastfeeding. Semaglutide should be stopped in advance of a planned pregnancy — discuss timing with your physician.

How semaglutide is administered

Semaglutide is a once-weekly subcutaneous injection delivered with the pen included in your protocol. Your physician prescribes your starting dose, typically increases it gradually over several months, and adjusts it based on your response and side effects. Do not change your dose or dosing schedule on your own — dose questions, including missed doses, belong in a portal message to your physician.

Tell your physician before starting

• Any history of pancreatitis, gallbladder disease, or kidney problems.
• Diabetes, and any use of insulin or sulfonylureas — combining these with semaglutide can cause low blood sugar.
• A history of diabetic retinopathy, which can temporarily worsen with rapid blood-sugar improvement.
• Any history of depression, suicidal thoughts, or other mental-health conditions.
• A history of disordered eating.
• All medications and supplements you take. Semaglutide slows stomach emptying and can affect how oral medications are absorbed.
• If you are pregnant, planning pregnancy, or breastfeeding.

Serious side effects

Stop using semaglutide and seek medical care right away if you experience any of the following:

• Inflammation of the pancreas (pancreatitis): severe, persistent abdominal pain that may radiate to your back, with or without vomiting.
• Gallbladder problems: pain in the upper right abdomen, fever, yellowing of the skin or eyes, or clay-colored stools.
• Serious allergic reaction: swelling of the face, lips, tongue, or throat; difficulty breathing or swallowing; severe rash; rapid heartbeat. Call 911.
• Low blood sugar (especially with insulin or sulfonylureas): dizziness, shakiness, sweating, confusion, blurred vision, slurred speech.
• Kidney injury from dehydration: prolonged vomiting or diarrhea that prevents you from keeping fluids down requires prompt medical attention.
• Changes in vision, particularly if you have diabetic retinopathy.
• New or worsening depression or thoughts of self-harm. If you are in crisis, call or text 988.

Common side effects

The most common side effects are digestive and tend to occur early in treatment and around dose increases, then ease as your body adjusts: nausea, vomiting, diarrhea, constipation, abdominal pain, indigestion, fatigue, and mild injection-site reactions. Tell your physician about side effects at your check-ins — dose pace is adjustable, and persistent or severe symptoms should not be pushed through.

Reporting side effects

If you experience a medical emergency, call 911. For urgent but non-emergency concerns, message your physician through the Conduit portal — clinical messages are reviewed promptly.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.