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NAD+ and sermorelin, explained properly
The two therapies inside the Vitality protocol: what each one actually does, what the evidence says and does not say yet, and what the first months tend to feel like.
The problem both therapies point at
The tiredness that arrives in your late 30s and 40s is rarely one thing. Sleep gets lighter and repairs less. Cellular energy production gets less efficient. Recovery from a hard week starts taking longer than the week itself. Coffee patches a morning; it does not touch the machinery underneath.
The Vitality protocol works on that machinery from two directions: NAD+ for the energy economy your cells run on all day, and sermorelin for the overnight hormone rhythm that does your repair work. Two therapies, one protocol, one physician watching how you respond.
What NAD+ is
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every living cell. It is the shuttle your mitochondria use to convert what you eat into usable energy, and it is a required ingredient for hundreds of repair enzymes, including the sirtuins that maintain DNA.
Levels are not stable across life. NAD+ declines steadily with age, and researchers have connected that decline to the drop in cellular energy and repair capacity that people feel as fatigue and slow recovery. Supplementation restores circulating levels. Injection delivers it directly, which is why clinics built the therapy around injectable and IV forms rather than oral supplements with uncertain absorption.
The honest sentence about the evidence: the biochemistry above is textbook and undisputed, restoration of levels is measurable, and the large randomized trials that would tie restoration to specific human outcomes are still being run. We tell you that plainly because a protocol you trust has to start with claims you can check.
What sermorelin is
Sermorelin is a fragment of growth hormone releasing hormone, the signal your brain sends the pituitary to release growth hormone. It has been used clinically since the 1990s. It does not add outside growth hormone to your body; it prompts your own pituitary to release it in the natural pulsed rhythm, mostly during deep sleep.
That distinction matters for safety and for how it feels. Because the release stays under your body’s own feedback control, levels stay in a physiologic range. And because the release happens overnight, the first change members typically report is sleep that feels deeper and mornings that feel less like a negotiation.
Two therapies, two jobs
Why the protocol pairs them rather than choosing one.
| NAD+ | Sermorelin |
|---|---|
| Daytime cellular energy production | Overnight repair and recovery rhythm |
| Restores a coenzyme that declines with age | Prompts your own hormone release, physiologically |
| Felt as steadier energy across the day | Felt first as deeper sleep, then better mornings |
| Evidence: established biochemistry, maturing human outcome data | Evidence: decades of clinical use as a secretagogue |
Your physician doses each independently and adjusts monthly based on your check-ins, so the protocol you are on in month four reflects how you actually responded to months one through three.
What the first months tend to feel like
Every response is individual. This is the arc members most often describe.
- Weeks 1 to 3
Sleep shifts first
Deeper sleep is usually the earliest signal, often before anything else changes. Some members notice more vivid dreams as sleep architecture shifts.
- Months 1 to 2
Mornings level out
The wake-up tax shrinks. Energy through the day gets steadier rather than spiking and cratering.
- Months 2 to 4
Capacity returns
Training recovery, afternoon focus, and the general sense of headroom are where members report the compounding change.
Who this is not for
Sermorelin is not prescribed with active cancer or a history of certain tumors, and NAD+ dosing is adjusted or declined around some conditions your physician screens for at intake. Pregnancy rules both out. This is exactly why the protocol is physician-gated: the screen exists to find the people who should not be on it.
Questions members actually ask
Is this a stimulant? Will it feel like caffeine?
No. Neither therapy is a stimulant. The change members describe is the absence of the crash rather than the presence of a buzz: steadier energy, better sleep, faster recovery. If you are looking for an acute jolt, this is the wrong tool.
Why injections instead of NAD+ pills?
Oral NAD+ precursors face an absorption question that injectable delivery sidesteps: injection delivers the compound directly rather than through digestion. The protocol uses the pre-filled pen you already know from every Conduit protocol, one quick click.
Does this replace my growth hormone?
No, and that is the point. Sermorelin prompts your own pituitary to release growth hormone under your body’s natural feedback control. Nothing external overrides your physiology, which is the safety difference between a secretagogue and hormone replacement.
How fast will I feel something?
Sleep changes commonly show inside the first month; energy and recovery build over two to four. Your monthly check-ins tell your physician how you are responding, and the dosing is tuned to that. If nothing has moved by your second check-in, that is a conversation, not a shrug.
Sources
This guide is educational and is not medical advice. It restates the Conduit clinical protocol in plain language; your physician’s individual guidance always comes first. If you are experiencing a medical emergency, call 911.